The series' premise originated with Paul Attanasio, while David Shore, who is credited as creator, was primarily responsible for the conception of the title character. Gregory House ( Hugh Laurie), an unconventional, misanthropic medical genius who, despite his dependence on pain medication, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital (PPTH) in New Jersey. House (also called House, M.D.) is an American medical drama television series that originally ran on the Fox network for eight seasons, from November 16, 2004, to May 21, 2012.